| Week | Date | Opponent | Time | TV |
|---|---|---|---|---|
| 1 | Sept. 10 | @ Pittsburgh | 1:00 PM | FOX |
| 2 | Sept. 17 | @ LA Rams | 4:05 PM | FOX |
| 3 | Sept. 21 | vs NY Giants | 8:15 PM | PRIME |
| 4 | Oct. 1 | vs Arizona | 4:25 PM | FOX |
| 5 | Oct. 8 | vs Dallas | 8:20 PM | NBC |
| 6 | Oct. 15 | @ Cleveland | 1:00 PM | FOX |
| 7 | Oct. 23 | @ Minnesota | 8:15 PM | ESPN |
| 8 | Oct. 29 | vs Cincinnati | 4:25 PM | CBS |
| 9 | BYE WEEK | |||
| 10 | Nov. 12 | @ Jacksonville | 1:00 PM | FOX |
| 11 | Nov. 19 | vs Tampa Bay | 4:05 PM | FOX |
| 12 | Nov. 23 | @ Seattle | 8:20 PM | NBC |
| 13 | Dec. 3 | @ Philadelphia | 4:25 PM | FOX |
| 14 | Dec. 10 | vs Seattle | 4:05 PM | FOX |
| 15 | Dec. 17 | @ Arizona | 4:05 PM | CBS |
| 16 | Dec. 25 | vs Baltimore | 8:15 PM | ABC |
| 17 | Dec. 31 | @ Washington | 1:00 PM | FOX |
| 18 | Jan. 7 | vs LA Rams | TBD | TBD |
San Francisco 49ers
by
Wallace Writing 
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